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In multiple data sources, scientists  found gastroesophageal reflux disease (GERD) patients exposed to PPIs to have a 1.16 fold increased association (95% CI 1.09-1.24) with myocardial infarction. Survival analysis in a prospective cohort found a two-fold (HR = 2.00; 95% CI 1.07-3.78; P = 0.031) increase in association with cardiovascular mortality. Scientists  found that this association exists regardless of clopidogrel use. Scientists queried over 16 million clinical documents on 2.9 million individuals to examine whether PPI usage was associated with cardiovascular risk in the general population.

http://www.ncbi.nlm.nih.gov/pubmed/?term=Shah+NH%2C+LePendu+P%2C+Bauer-Mehren+A%2C+et+al.+Proton+pump+inhibitor+usage+and+the+risk+of+myocardial+infarction+in+the+general+population.+PLoS+One.+2015%3B10%3Ae124653.