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USPSTF Finalizes Statin Recommendations for CVD Prevention

 

The US Preventive Services Task Force (USPSTF) released the final recommendations and evidence summary for the use of statins for the primary prevention of cardiovascular disease (CVD) in adults in the end of 2016. The final recommendations were published in the Journal of the American Medical Associations (JAMA).

Main points of the recommendations are as follows:

  • Low- to moderate-dose statins in adults aged 40 to 75 years who do not have a history of CVD but who do have one or more CVD risk factors (dyslipidemia, diabetes, hypertension, or smoking) and who have a 10% or greater risk of having a CVD event (myocardial infarction or stroke) over the next 10 years (B recommendation).
  • On the basis of a discussion with patients, clinicians should selectively offer low- to moderate-dose statins to adults aged 40 to 75 years who do not have a history of CVD but who have one or more CVD risk factors and a 7.5% to 10% risk for a CVD event in the next 10 years (C recommendation).
  • Evidence is insufficient for the benefits and harms of starting statins in adults 76 years and older (I statement).

Clinicians are advised to determine 10-year CVD risk using the pooled cohort equations developed by the American College of Cardiology/American Heart Association (ACC/AHA).

The new recommendations do not apply to patients at very high risk, such as individuals with familial hypercholesterolemia or those with low-density lipoprotein (LDL) levels over 190 mg/dL.

The recommendations are available online at www.uspreventiveservicestaskforce.org.