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In August the New EnglandJournal of Medicine published the results of RURE study. PURE is a large, international epidemiologic study that was designed to understand risk factors for CVD and diabetes. It enrolled adults aged 35 to 70 in 17 low-, middle-, and high-income countries on all continents.

The first study showed that for each 1-g increase in estimated sodium excretion, there was a 2.11-mm-Hg increase in systolic blood pressure and a 0.78-mm-Hg increase in diastolic blood pressure. The slope was steeper for people with higher sodium intake or hypertension or older age. Potassium excretion was inversely linked with systolic blood pressure.

Compared with the reference range, those with the highest sodium excretion (>7.00 g/day) had a 15% increased risk and those with the lowest sodium excretion (<3.00 g/day) had a 27% increased risk of the composite outcome.