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 Smoking is associated with worse clinical outcomes, especially MI, following coronary revascularization, indicating that there is no "smoker"s paradox" when smoking status is accounted for across time, the SYNTAX trial shows[1].The study was published in the March 24, 2015 issue of the Journal of the American College of Cardiology.

At 5 years, smoking was associated with a 38% increased risk of the composite end point of death, MI, or stroke (hazard ratio [HR] 1.38, 95% CI 1.02–1.86; P=0.035).

Smoking was also associated with a 28% increased risk of major adverse cardiac and cerebrovascular (MACCE) events (HR 1.28, 95% CI 1.01–1.61; P =0.041).

  1. Zhang YJ, Iqbal J, van Klaveren D, et al. Smoking is associated with adverse clinical outcomes in patients undergoing revascularization with PCI or CABG. J Am Coll Cardiol 2015; 65:1107-1115. Abstract
  2. Kirtane A, Kelly C. Clearing the air on the "smoker"s paradox." J Am Coll Cardiol 2015; 65:1116-1117. -