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Coronary Calcium Promotes AF in "Dose-Response" Fashion: MESA

 Progression of coronary artery calcification appears to raise atrial fibrillation in a "dose-dependent" fashion, suggests new findings from the Multi-Ethnic Study of Atherosclerosis (MESA).The younger population in the study with higher levels of CAC had a higher risk of AF development. A total of 203 cases of AF (3.6%) were seen over a median of 5.6 years. Patients with CAC progression had a cumulative incidence of AF over three times higher than those without CAC progression (respective incidence rates 10.0; 95% CI 8.6–11.7 vs 3.0; 95% CI 2.2–3.9). Patients with any CAC progression had a 55% increased risk of developing AF (HR 1.55; 95% CI 1.10–2.19) after adjustment for age, sex, race/ethnicity, education, income, baseline CAC, any CAC progression, smoking, body-mass index, diabetes, systolic blood pressure, total cholesterol, high-density lipoprotein, antihypertensive medications, lipid-lowering therapies, aspirin, and left ventricular hypertrophy.