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Are Primary-Prevention ICDs Still Right for Nonischemic Heart Failure? DANISH Says No

With contemporary heart-failure therapies, it seems that an implantable cardioverter defibrillator (ICD) for primary prevention does not improve long-term survival in patients with nonischemic cardiomyopathy, whether or not they are also getting cardiac resynchronization therapy (CRT), suggests a major randomized trial.

But secondarily there was confirmation that the ICD implants do cut the risk of sudden cardiac death overall. And that they probably prolong survival in one subgroup that researchers and some observers say may represent the most appropriate population for the devices among patients with nonischemic heart failure.

In the Danish Study to Assess the Efficacy of ICDs in Patients With Nonischemic Systolic Heart Failure on Mortality (DANISH) was presented at European Society of Cardiology (ESC) 2016 Congress and published  in the New England Journal of Medicine.