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HARMONY: Same BP Effect for Morning vs Night Antihypertensive Med Dosing

Taking antihypertensive medications during evening or morning hours makes no difference when it comes to 24-hour ambulatory blood-pressure monitoring (ABPM) levels in patients with hypertension, suggests new research. The Hellenic-Anglo Research Into Morning or Night Antihypertensive Drug Delivery (HARMONY) study is a randomized, crossover trial of 95 hypertension patients in the UK and Greece. It showed almost identical results whether meds were taken in the morning between 6:00 and 11:00 or in the evening between 6:00 and 11:00, with regard to the primary end point of mean 24-hour systolic BP (129.65 and 129.75 mm Hg, respectively).

There was also no significant difference between delivery times for mean 24-hour diastolic BP, mean daytime SBP, mean daytime and nighttime DBP, and mean clinic SBP and DBP. In addition, quality-of-life scores did not differ.

The most common class type of antihypertensive used at both centers was renin-angiotensin-system blockers (about 80% use), followed by calcium-channel blockers. And the mean number of drugs taken was two.