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Work stress and risk of death in men and women with and without cardiometabolic disease: a multicohort study

Evidence from  pooling of individual-participant data from seven European cohort studies suggests that job strain is a risk factor for mortality in men with cardiometabolic disease, as defined by the presence of coronary heart disease, stroke, or diabetes. The mortality difference between groups with and without job strain was clinically significant and independent of socioeconomic status, the conventional and lifestyle risk factors measured (current smoking, obesity, physical inactivity, high alcohol consumption, hypertension, dyslipidaemia), and pharmacotherapy.