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RE-LY: NSAIDs Plus Anticoagulants a Dangerous Combination

Concomitant use of nonsteroidal anti-inflammatory drugs (NSAIDs) and oral anticoagulants in patients with atrial fibrillation (AF) increases the risk for major bleeding and stroke, according to a new analysis of the RE-LY trial.

In this post hoc analysis of the RE-LY study investigators found that concomitant NSAID use with any anticoagulant increases extracranial risk particularly, as well as stroke risk in patients with AF. Results of study were published July 9 in the Journal of the American College of Cardiology.

J Am Coll Cardiol. 2018;72:255-267, 268-270.