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The relationship between smoking cessation and survival in young people with myocardial infarction in The Partners YOUNG-MI registry


Despite significant progress in primary prevention of cardiovascular disease, the incidence of myocardial infarction (MI) continues to rise in young people. The authors of the study posed the question: is smoking cessation associated with lower mortality among young people after MI? The Partners YOUNG-MI registry is a retrospective cohort study conducted at 2 major academic centers in Boston, Massachusetts that includes MI patients aged 50 years and younger. The participants were 2,072 people with a history of MI under the age of 50 between January 2000 and April 2016. The analysis was carried out from October to December 2019. Among 2072 people (mean age 45), 1669 [80.6%] were men, and 1088 (52.5%) were smokers at the time of their hospitalization for MI. It turned out that those who quit smoking had a statistically significantly lower mortality rate from all causes (risk ratio [RR] 0.35; 95% CI 0.19-0.63; P <0.001) and cardiovascular mortality (RR 0.29; 95% CI 0.11-0.79; P = 0.02).Thus, in this cohort study, approximately half of the MI patients under the age of 50 were active smokers. Smoking cessation within 1 year after MI was associated with a more than 50% reduction in all-cause and cardiovascular mortality.


Association of Smoking Cessation and Survival Among Young Adults With Myocardial Infarction in the Partners YOUNG-MI Registry

David W. Biery, AB;Adam N. Berman, MDAvinainder Singh, MBBS, MMScSanjay Divakaran, MDErsilia M. DeFilippis, MDBradley L. Collins, MDAnkur Gupta, MD,PhDAmber Fatima, MBBSArman Qamar, MDJosh Klein, BSJon Hainer, BSMichael J. Blaha, MD, MPHMarcelo F. Di Carli, MDKhurram Nasir, MD, MPHDeepak L. Bhatt, MD, MPHRon Blankstein, MD

JAMA Netw Open. 2020;3(7):e209649.